Down’s syndrome is caused by most common genetic mutation that affects every cell in the body. It is a very complex condition and needs to be managed by multidisciplinary team of nurses, physicians, psychologists, speech therapists and educational rehabilitators. This condition can be detected and diagnosed during pregnancy or at child’s birth because of the specific facial features. Nurses have a major role in mother’s education since birth, from breast feeding to managing various difficulties expected in children with Down’s syndrome in first few months of life. Children and parents face many health issues and difficulties and they need a lot of commitment and education provided by nurses. Holistic healing approaches the human being in every aspect of his life, physical, psychological, sociological and spiritual. Only through holistic nursing we can comprehend Down’s syndrome and how it affects child’s life. High-quality health care, parental education, baby handling and early intervention are mandatory in improving child’s acquisition of basic life skills. Mainstream school integration is very important for equality of all children, especially children with Down’s syndrome. Several non-profit organizations for individuals with Down’s syndrome and their families offer support in social integration, education and communication and help improve their lives. Individuals with Down’s syndrome experience many health issues which can be identified and solved with nursing diagnosis and nursing care planning.