Natural healing factors are part of the nature that have healing properties. In Croatia they are very widespread, but their usability is very low. Natural healing factors can be divided into 3 groups: climatic, marine and thermal(balneological). One of the biggest natural healing factor in Croatia is the sea and everything related to it(climate, vegetation, algae, etc.), while most spas are located in the continental part of Croatia. The reason for that is the soil which is very rich in minerals. Hydrotherapy and balneotherapy are conservative therapy methods that have a very wide application in various diseases, some of which are: rheumatic, neurological, dermatological, etc. and are very often use din combination with other methods of physical therapy such as kinesitherapy. Their effect is attributed to the physical properties of water and the healing properties of minerals that have anti-inflammatory effects, reduce pain and muscle stiffness, stimulate circulation and thereby the person feels better mentally. Some of the health resorts located in the continental part of Croatia are Krapinske, Daruvar and Topusko spas. These spas have a very long history,large selection of physical therapy methods, but are also wealthy in minerals. In order for Croatia to make the most of its natural resources, further investments in modernization of entire health tourism are needed. In general, natural healing factors and their application are still insufficiently researched, but most research shows their positive effects on the entire human body.