For the last two years of life, the world has been fighting the SARS-CoV-2 virus and the COVID-19 disease that the virus causes. In addition to all the difficulties caused by the disease itself, there are difficulties which accompany it and which accompany the prevention measures against COVID-19. Thus, more and more people suffer from the difficulties with mental health and the deteriorated quality of life. Therefore, the aim of this paper was to examine the attitudes of undergraduate professional studies of sorority on the impact of the COVID-19 pandemic on their quality of life in the aspect of social isolation and new teaching methods (online). 87 respondents, full-time and part-time students of undergraduate professional studies of sorority, University of Rijeka, participated in the survey. Data subjects were sent a link to a survey made in the Google forms form to an official email address via Outlook. The survey consisted of two parts, the first part included 5 general socio-demographic data on the respondent and the second part consisted of 15 questions with the possibility of choosing a response on the Licerto scale from 1 to 5. The results obtained in this study show that the examinees at the undergraduate nursing study felt a negative impact of the COVID-19 pandemic on the quality of life, but not to a large extent due to the average of the points of their answers of 2.67 out of the possible 5 for the full-time student and 2.61 out of 5 for the exceptional ones in the range between 2 (mostly not for me) and 3 (nor does it apply to me). Accordingly, as a final result, it was obtained that hypothesis 1 is rejected p > 0.05 while hypothesis 2 accepts p < 0.05. The conclusion is that this topic is very interesting for research and that such investigations should certainly be carried out on a large number of subjects in order to reduce the consequences of the COVID-19 disease pandemic.