The World Health Organization defines burnout syndrome as a phenomenon caused by an imbalance between long-term exposure to stress at the workplace and the level of ability to cope with stress (1). The burnout syndrome leads to a loss of will, the meaningfulness of work and the efficiency of workers, and as a result, reduced productivity at work occurs (2). The goal of the research was to determine the incidence of burnout syndrome among nurses and technicians employed in branches of the Istrian health centers, which was intended to provide insight into the level of burnout among employees for the purpose of preventing or solving this phenomenon. The research was conducted through an anonymous survey among nurses and technicians employed in Istrian health centers in May 2022. 101 respondents were included in the research - health workers from all branches of the Istrian health centers, different workplaces, from 18 to 65 years of age. The survey was distributed through direct contact with respondents. The instrument consisted of a questionnaire made up of two parts: a questionnaire on sociodemographic data created for this research and the Croatian version of the Oldenburg Burnout Questionnaire, authored by Irena Burić and Ana Slišković (3). The obtained research results indicate a high incidence of burnout syndrome among the employees of the Istrian health centers. The research resulted in a finding contrary to one of the set hypotheses, as it follows that employees with fewer years of service experience a higher degree of burnout. The results related to the specific workplace and the frequency of burnout syndrome did not show a statistically significant difference.