INTRODUCTION: Since its establishment, Bizovačke toplice spa has provided prosthetics and rehabilitation of amputees, who make up an average of 5% of all patients. Research related to the quality of life for patients after amputation of the lower extremities is extremely rare, considering the small number of health institutions that deal with this type of rehabilitation. Current projections for the Republic of Croatia and projections by the World Health Organization predict an increase of people with diabetes mellitus, which will indirectly affect the number of patients with lower limb amputations. MATERIALS AND METHODS: 61 lower limb amputation patients between ages of 18-80 with unilateral amputation or bilateral transtibial and/or transfemoral amputation of both limbs participated in the study. All patients were referred for the first prosthetic fitting and prosthetic rehabilitation for 21 days at the Bizovačke toplice spa. The research included all patients between 01.01.2021-01.04.2022. The questionnaires used in the research are: a questionnaire with general information and two specific questionnaires: for the self-assessment of health SF-36 (Short form 36 Health Survey Questionnaire), the questionnaire for assessing the functional outcomes of the PPA (The Prosthetic Profile of the Amputee Person questionnaire) and sub-questionnaire LCI (Locomotor Capabilities Index). RESULTS: The results obtained through the questionnaire indicate the existence of statistically significant differences through the connection between the self-assessment of the quality of life and the degree of satisfaction with the results of prosthetic supply and rehabilitation. All domains of the SF-36 questionnaire correlate significantly in relation to the prosthesis itself (comfort, appearance, weight and walking with the prosthesis). Likewise, all domains of the SF-36 questionnaire significantly correlate with the LCI, which confirms that a higher level of locomotor abilities means a higher level of satisfaction, which is also the result of the rehabilitation itself. The result of rehabilitation is the use of the prosthesis itself on a daily and weekly level, where there are significant correlations with the LCI value. Also, the physiotherapy approach itself contributed to the fact that all domains of the SF-36 questionnaire significantly correlate with the acceptance of amputation and prosthesis. CONCLUSION: Assessment of the quality of life for patients after lower limb amputation should be an integral part of rehabilitation. Quality prosthetic supply is also the result of the rehabilitation institution's physiotherapist, who plays an important role when recommending the modules that will be an integral part of the prosthesis. High-quality rehabilitation programs and the physiotherapy approach itself have been proven in this research.