The aim of this research was to examine whether there is a difference in the degree of burnout at work and the way of coping with stress between physiotherapists who worked in the COVID-19 respiratory center, in the COVID-19 departments and those who were not assigned to the COVID-19 workplaces. 91 respondents participated in the research. The research was conducted among physiotherapists working in the public health in the Republic of Croatia. The first part of the questionnaire was consisted of general questions and questions related to the COVID-19 infection. The second part was a Burnout inventory scale, and the third part was Ways of coping questionnaire, a shortened version of the questionnaire. Standardized online questionnaires were used. There was a statistically significant difference in the degree of burnout at work in the group of respondents who spent more than 6 months in the COVID-19 respiratory center compared to the other respondents. Initial signs of job burnout were observed in respondents who worked in a COVID-19 respiratory center. There is a statistically significant difference between respondents who spent more than 6 months in the COVID-19 departments compared to respondents who did not work in the COVID-19 departments. Initial signs of burnout at work were observed in male respondents from the entire group, and there is a statistically significant difference in coping with stress between male and female respondents. The method of dealing with stress focused on avoidance is more common among female respondents. The research was conducted on a relatively small sample and in the later phase of the pandemic, so the results should be interpreted carefully.