INTRODUCTION: Chronic kidney disease is a progressive condition characterized by structural and functional changes in the kidneys due to various causes. Hemodialysis (HD) is a technique used to achieve extracorporeal removal of waste products such as urea and creatinine and excess water from the blood when the kidneys are in a state of failure. Learning to live with chronic kidney disease, an AV fistula, and the prospect of having to undergo hemodialysis every three days can seem like a big deal. Therefore, it is important to assess the quality of life of patients on hemodialysis, which will enable a better understanding and improvement of it. OBJECTIVE: To assess the quality of life of people undergoing hemodialysis at the Hemodialysis Department of the Šibenik General Hospital. RESULTS: Out of 29 respondents, 14 (48%) belong to the group over 70 years old, which is the most represented group. Men are slightly more represented than women and make up 55% of the population. Considering the duration of the disease for more than 15 years, 59% of respondents have been ill, 10% of them have been ill from 11 to 15 years and 31% for up to five years. The average quality of life rating is 3.4 ±0.6 out of a possible 5, of which the youngest group rated their life the highest, and the oldest group the lowest, but this difference was not statistically significant. As for the overall quality of life index, it is the lowest in the youngest age group, and the highest in the oldest age group, but this difference was not statistically significant. CONCLUSION: Chronic kidney disease is a major public health problem today, and it is caused by the modern way of life and the general aging of the population. Thanks to the development of science and nephrology medicine, there are satisfactory ways of its treatment, and one of them is hemodialysis. The nurse takes care of the patient's needs from the very beginning of the treatment and continuously throughout the entire process of hemodialysis. Such care requires the possession of certain knowledge and skills in the field of nephrology and continuous lifelong education, in order to be able to provide the maximum quality of health care.