Introduction: Aortic stenosis is the most common form of heart valve disease in developed countries, affecting 3% of the world's population over the age of 65. The standard method of treating a symptomatic patient is surgical replacement of the valve. In patients with a high risk for surgery, the valve is implanted in a minimally invasive way, with a transcatheter approach. Research objective: Comparison of the transfemoral vs. transapical aortic valve implantation approach. The data that were compared were in-hospital and early postoperative mortality, complications due to the procedure, duration of hospitalization and stay in the intensive unit, left ventricular systolic function and patient life quality according to the NYHA classification. Subjects and methods: The research was conducted retrospectively on 99 patients hospitalized at KBC Rijeka in the period from 2015 to 2022. The data were collected from the hospital information system IBIS. Only patients who were implanted with an aortic valve manufactured by Edwards Lifesciences were included in the study because only their valves are implanted through a transfemoral and transapical approach. Results: The average age of the subjects was 81 ± 6,65 years. A statistically significant difference was found in the number of patients between the two groups, 83 patients participated in the transfemoral group, and 16 patients in the transapical group, p<0.001. Mortality was 6.06% and did not differ significantly between groups. There was no statistically significant difference between the groups in complications due to procedure or in the systolic function of the left ventricle. The duration of hospitalization differed significantly between the groups, the transfemoral group spent an average of 7,32 ± 5,23 days in the hospital, and the transapical 12,43 ± 4,67 days, p<0.001. The condition of the patients according to the NYHA classification significantly improved in both groups, there was no difference between the groups. Conclusion: The obtained results of this research led to the conclusion that, apart from the duration of hospitalization, there was no statistically significant difference between the TAVI procedure performed with the transfemoral approach versus the transapical approach. The duration of hospitalization on average is significantly shorter in patients who underwent the TAVI procedure with the transfemoral approach.