Holism (from ὅλος holos, a greek word meaning all, entire, total) is the principle according to which the living entity is a whole, irreparable to the parts. Hippocrates already (almost 2,500 years ago) advocated the idea that "the soul should be treated first, and then the body," and that the patient should "first be offered the word, and only then the drug" Contemporary medicine is aware of the fact that a man is treated, not a disease, is also shown by the fact that in the same illness different people do not achieve the same results although the same methods of treatment were used. Chronic Kidney Disease (KKD) is growing each day both in the world and in our areas. Precisely because of today's lifestyle, there are more and more patients with diabetes mellitus and elevated blood pressure, and they belong with chronic glomerulonephritis among the most common causes of KKD. Peritoneal dialysis has become a well established method of integrated treatment of the final degree of renal failure. It is recommended as the first method of choice for the treatment of chronic renal failure when there is a need for dialysis treatment. The advantages of peritoneal dialysis are that the remaining kidney function is maintained with it, as opposed to hemodialysis treatment, thereby achieving better quality of life and ultimately longer survival. A crucial factor for successful implementation of peritoneal dialysis is a collaborative patient. A nurse as an educator plays a crucial role in the success of treatment. The predialysis education program greatly contributes to the preparation of patients for peritoneal dialysis. Considering the fact that the peritoneal dialysis is a home treatment we are faced with many challenges. There is a necessary holistic approach to the patient. Through a holistic approach, we come to know the patient, his family, the psychological aspect of the patient, and the way that patient is functioning in everyday life. The basic guiding idea each health worker should have is not to treat the disease but the person so holistic approach is represented as a base of nursing care.