INTRODUCTION: Cardiac electrostimulation is one of the most modern methods of treating cardiac arrhythmias, and the nurse/technician as part of the medical team has a significant role in medical care and improving the quality of life of the patient. Therefore, lifelong learning and continuous improvement of the knowledge and skills of nurses/technicians during and after regular education is crucial in providing quality medical care. Objective of this research is to compare the knowledge of regular first-year Nursing students about permanent heart pacemakers and the care and quality of life of patients with an implanted permanent electrostimulator with the knowledge of second- and third-year students. MATERIALS AND METHODS: The research was conducted at the Faculty of Health Studies in Rijeka according to the "pencil-paper" principle. The research sample was students of both sexes, first, second, and third year of full-time undergraduate studies in Nursing. A total of 90 respondents participated in the research. Based on the results of the second and third part of the questionnaire, the results were classified into 3 groups: insufficient knowledge (≤ 9 points), medium knowledge (10 to 16 points) and enviable knowledge (> 16 points). The collected data were statistically processed using the Microsoft Excel and Statistica 13.3 (TIBCO). RESULTS: Comparing the sum of points per year, for the part of the questionnaire that assesses students' knowledge about permanent cardiac electrostimulation, it can be seen that the largest number of students from the first year had 13 points out of a total of 20, and thus they are very close to the knowledge of students from the third year, where the largest number of respondents had 14 points. The second year had the weakest results in this part of the questionnaire (the highest number of students had 11 points). In the part of the questionnaire, which assesses students' knowledge of the quality of life of patients with an implanted permanent pacemaker, all three years achieved equal results, varying between 15 and 17 points. There is no statistically significant difference in the knowledge between the first year of full-time nursing studies, compared to the second and third years, about permanent cardiac pacemakers (p=0.41) and about the quality of life of patients with implanted permanent pacemakers (p=0.11). CONCLUSION: students of all three years of study have intermediate knowledge about permanent cardiac electrostimulator, which is why it is necessary to further improve the quality of teaching and improve knowledge in postgraduate specialist training, in order to continuously improve the care of patients with permanent cardiac ES and their quality of life.