Introduction and research objectives: Amputation is a surgical procedure that removes a part of the body or an organ. During amputation, the soft parts are removed together with the bones. Amputation is used for diseases and injuries in which there is no possibility of healing or for severe infections and the existence of malignant growths where there is a danger to the whole organism. The main cause of lower limb amputation is vascular diseases. The research analyzed the frequency of lower limb amputations with regard to age, gender and level of amputation. Materials and methods: The respondents are patients who, in the period from January 1st 2019 to December 31st 2022 stayed at the Department of Vascular Surgery in Zadar General Hospital. The inclusion criteria are subjects aged 18-90 who underwent lower limb amputation surgery. Data were collected from the hospital’s IT system, and a statistical analysis was conducted. The ethical aspects of research related to the confidentiality and protection of patient data are respected. Results: A total of 556 respondents were recorded, of which 405 were male and 151 were female. The research carried out for the purpose of this paper showed that men and those of an older age make up a larger proportion of patients with amputated lower limbs compared to women. There was no statistically significant association between the age of the patients and the frequency of lower limb amputation. In injury mechanisms, falls and traffic accidents were the most common. Conclusion: This research on the frequency of lower limb amputations in the period from 2019 to 2022 at the Zadar General Hospital provided insight into the socio-demographic characteristics of patients, mechanisms of injury and etiology and pathophysiology of the disease, approach to treatment and treatment outcomes. Most patients undergo amputation surgery as the main form of treatment for an injury or illness.