prikaz prve stranice dokumenta Angiogenesis and osteopontin expression in paraskeletal myeloma with plasmablastic morphology and aggressive clinical course: a report of two cases
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Scientific paper - Case study
Angiogenesis and osteopontin expression in paraskeletal myeloma with plasmablastic morphology and aggressive clinical course: a report of two cases
Journal of Cancer Metastasis and Treatment, 8 (2022); 4783. https://doi.org/10.20517/2394-4722.2021.208
Valković, Toni; Damić, Marija Stanić; Valković, Frane; Jonjić, Nives

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Valković, T., Damić, M. S., Valković, F. & Jonjić, N. (2022). Angiogenesis and osteopontin expression in paraskeletal myeloma with plasmablastic morphology and aggressive clinical course: a report of two cases. Journal of Cancer Metastasis and Treatment, 8., 16. doi: 10.20517/2394-4722.2021.208

Valković, Toni, et al. "Angiogenesis and osteopontin expression in paraskeletal myeloma with plasmablastic morphology and aggressive clinical course: a report of two cases." Journal of Cancer Metastasis and Treatment, vol. 8, 2022, pp. 16. https://doi.org/10.20517/2394-4722.2021.208

Valković, Toni, Marija Stanić Damić, Frane Valković and Nives Jonjić. "Angiogenesis and osteopontin expression in paraskeletal myeloma with plasmablastic morphology and aggressive clinical course: a report of two cases." Journal of Cancer Metastasis and Treatment 8 (2022): 16. https://doi.org/10.20517/2394-4722.2021.208

Valković, T., et al. (2022) 'Angiogenesis and osteopontin expression in paraskeletal myeloma with plasmablastic morphology and aggressive clinical course: a report of two cases', Journal of Cancer Metastasis and Treatment, 8, pp. 16. doi: 10.20517/2394-4722.2021.208

Valković T, Damić MS, Valković F, Jonjić N. Angiogenesis and osteopontin expression in paraskeletal myeloma with plasmablastic morphology and aggressive clinical course: a report of two cases. Journal of Cancer Metastasis and Treatment [Internet]. 2022 [cited 2024 May 06];8:16. doi: 10.20517/2394-4722.2021.208

T. Valković, M. S. Damić, F. Valković and N. Jonjić, "Angiogenesis and osteopontin expression in paraskeletal myeloma with plasmablastic morphology and aggressive clinical course: a report of two cases", Journal of Cancer Metastasis and Treatment, vol. 8, pp. 16, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:103873. [Accessed: 06 May 2024]

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Title (english)Angiogenesis and osteopontin expression in paraskeletal myeloma with plasmablastic morphology and aggressive clinical course: a report of two cases
AuthorToni Valković
AuthorMarija Stanić Damić
AuthorFrane Valković
AuthorNives Jonjić
Author's institutionUniversity of Rijeka
Faculty of Health Studies
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Extramedullary disease (EMD) of multiple myeloma (MM) can present as paraskeletal (paraosseous) plasmocytoma (PP) that arise from skeletal focal lesions or extramedullary plasmacytomas (EMP) that derive from hematogenous spread. The pathogenetic mechanisms that distinguish classical MM, PP, and EMP are still insufficiently known, as are the therapies that would be effective in EMD. The aim of this study was to evaluate immunohistochemically the angiogenesis, determined as microvessel density (MVD) and osteopontin expression in PP, of two patients with MM of plasmablastic morphology and an aggressive course of disease. We found high levels of MVD and osteopontin expression in both cases of PP. The role of angiogenesis and osteopontin in EMD should be clarified in future investigations, especially since there are no satisfactory therapeutic protocols for this form of multiple myeloma, and both of these biological factors can be the potential targets of new therapies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Cancer Metastasis and Treatment
Numberingvol. 8, p. 16, 4783
e-ISSN2454-2857
DOIhttps://doi.org/10.20517/2394-4722.2021.208
URN:NBNurn:nbn:hr:184:103873
Publication2022
Document URLhttps://jcmtjournal.com/article/view/4783
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-01-15 13:26:59