Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings

Rossi, Giuseppe; Salmanton-García, Jon; Cattaneo, Chiara; Marchesi, Francesco; Dávila-Valls, Julio; Martín-Pérez, Sonia; Itri, Federico; López-García, Alberto; Glenthøj, Andreas; Gomes da Silva, Maria; Besson, Caroline; Marchetti, Monia; Weinbergerová, Barbora; Jaksic, Ozren; Jiménez, Moraima; Bilgin, Yavuz M.; Van Doesum, Jaap; Farina, Francesca; Žák, Pavel; Verga, Luisa; Collins, Graham P.; Bonuomo, Valentina; Van Praet, Jens; Nucci, Marcio; Meers, Stef; Espigado, Ildefonso; Fracchiolla, Nicola S.; Valković, Toni; Poulsen, Christian Bjørn; Čolović, Natasha; Dragonetti, Giulia; Ledoux, Marie-Pierre; Tascini, Carlo; Buquicchio, Caterina; Blennow, Ola; Passamonti, Francesco; Machado, Marina; Labrador, Jorge; Duarte, Rafael F.; Schönlein, Martin; Prezioso, Lucia; Falces-Romero, Iker; Kulasekararaj, Austin; Garcia-Vidal, Carolina; Fernández, Noemí; Abu-Zeinah, Ghaith; Ormazabal-Vélez, Irati; Adžić-Vukičević, Tatjana; Piukovics, Klára; Stoma, Igor; Cuccaro, Annarosa; Magliano, Gabriele; Szotkowski, Tomáš; González-López, Tomás-José; El-Ashwah, Shaimaa; Bergantim, Rui; Sili, Uluhan; Maertens, Johan; Demirkan, Fatih; De Ramón, Cristina; Petzer, Verena; Del Principe, Maria Ilaria; Navrátil, Milan; Dargenio, Michelina; Seval, Guldane Cengiz; Samarkos, Michail; Ráčil, Zdeněk; Pinczés, László Imre; Lahmer, Tobias; Busca, Alessandro; Méndez, Gustavo-Adolfo; Vena, Antonio; Biernat, Monika M.; Merelli, Maria; Calbacho, Maria; Barać, Aleksandra; Bavastro, Martina; Limongelli, Alessandro; Ilhan, Osman; Wolf, Dominik; Çolak, Gökçe Melis; García-Sanz, Ramón; Emarah, Ziad; Mišković, Bojana; Gräfe, Stefanie K.; Mladenović, Miloš; Aiello, Tommaso Francesco; Núñez-Martín-Buitrago, Lucía; Nordlander, Anna; Arellano, Elena; Zambrotta, Giovanni Paolo Maria; Ammatuna, Emanuele; Cabirta, Alba; Sacchi, Maria Vittoria; Nunes Rodrigues, Raquel; Hersby, Ditte Stampe; Hanakova, Michaela; Rahimli, Laman; Cordoba, Raul; Cornely, Oliver A.; Pagano, Livio

doi:10.1016/j.ijid.2023.10.013

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Scientific paper - Original scientific paper

Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings

International Journal of Infectious Diseases, 137 (2023); 98-110. https://doi.org/10.1016/j.ijid.2023.10.013

Rossi, Giuseppe; Salmanton-García, Jon; Cattaneo, Chiara; Marchesi, Francesco; Dávila-Valls, Julio; Martín-Pérez, Sonia; Itri, Federico; López-García, Alberto; Glenthøj, Andreas; Gomes da Silva, Maria; Besson, Caroline; Marchetti, Monia; Weinbergerová, Barbora; Jaksic, Ozren; Jiménez, Moraima; Bilgin, Yavuz M.; Van Doesum, Jaap; Farina, Francesca; Žák, Pavel; Verga, Luisa; Collins, Graham P.; Bonuomo, Valentina; Van Praet, Jens; Nucci, Marcio; Meers, Stef; Espigado, Ildefonso; Fracchiolla, Nicola S.; Valković, Toni; Poulsen, Christian Bjørn; Čolović, Natasha; Dragonetti, Giulia; Ledoux, Marie-Pierre; Tascini, Carlo; Buquicchio, Caterina; Blennow, Ola; Passamonti, Francesco; Machado, Marina; Labrador, Jorge; Duarte, Rafael F.; Schönlein, Martin; Prezioso, Lucia; Falces-Romero, Iker; Kulasekararaj, Austin; Garcia-Vidal, Carolina; Fernández, Noemí; Abu-Zeinah, Ghaith; Ormazabal-Vélez, Irati; Adžić-Vukičević, Tatjana; Piukovics, Klára; Stoma, Igor; Cuccaro, Annarosa; Magliano, Gabriele; Szotkowski, Tomáš; González-López, Tomás-José; El-Ashwah, Shaimaa; Bergantim, Rui; Sili, Uluhan; Maertens, Johan; Demirkan, Fatih; De Ramón, Cristina; Petzer, Verena; Del Principe, Maria Ilaria; Navrátil, Milan; Dargenio, Michelina; Seval, Guldane Cengiz; Samarkos, Michail; Ráčil, Zdeněk; Pinczés, László Imre; Lahmer, Tobias; Busca, Alessandro; Méndez, Gustavo-Adolfo; Vena, Antonio; Biernat, Monika M.; Merelli, Maria; Calbacho, Maria; Barać, Aleksandra; Bavastro, Martina; Limongelli, Alessandro; Ilhan, Osman; Wolf, Dominik; Çolak, Gökçe Melis; García-Sanz, Ramón; Emarah, Ziad; Mišković, Bojana; Gräfe, Stefanie K.; Mladenović, Miloš; Aiello, Tommaso Francesco; Núñez-Martín-Buitrago, Lucía; Nordlander, Anna; Arellano, Elena; Zambrotta, Giovanni Paolo Maria; Ammatuna, Emanuele; Cabirta, Alba; Sacchi, Maria Vittoria; Nunes Rodrigues, Raquel; Hersby, Ditte Stampe; Hanakova, Michaela; Rahimli, Laman; Cordoba, Raul; Cornely, Oliver A.; Pagano, Livio More authors...

Cite this document

APA 6th Edition

Rossi, G., Salmanton García, J., Cattaneo, C., Marchesi, F., Dávila Valls, J., Martín Pérez, S. ... Pagano, L. (2023). Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings. International Journal of Infectious Diseases, 137., 98-110. doi: 10.1016/j.ijid.2023.10.013

MLA 8th Edition

Rossi, Giuseppe, et al. "Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings." International Journal of Infectious Diseases, vol. 137, 2023, pp. 98-110. https://doi.org/10.1016/j.ijid.2023.10.013

Chicago 17th Edition

Rossi, Giuseppe, Jon Salmanton García, Chiara Cattaneo, Francesco Marchesi, Julio Dávila Valls, Sonia Martín Pérez, Federico Itri, et al. "Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings." International Journal of Infectious Diseases 137 (2023): 98-110. https://doi.org/10.1016/j.ijid.2023.10.013

Harvard

Rossi, G., et al. (2023) 'Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings', International Journal of Infectious Diseases, 137, pp. 98-110. doi: 10.1016/j.ijid.2023.10.013

Vancouver

Rossi G, Salmanton García J, Cattaneo C, Marchesi F, Dávila Valls J, Martín Pérez S, and sur.. Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings. International Journal of Infectious Diseases [Internet]. 2023 December [cited 2024 May 05];137:98-110. doi: 10.1016/j.ijid.2023.10.013

IEEE

G. Rossi, et al., "Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings", International Journal of Infectious Diseases, vol. 137, pp. 98-110, December 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:069393. [Accessed: 05 May 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:069393

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Metadata

Title (english)	Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings
Author	Giuseppe Rossi
Author	Jon Salmanton-García
Author	Chiara Cattaneo
Author	Francesco Marchesi
Author	Julio Dávila-Valls
Author	Sonia Martín-Pérez
Author	Federico Itri
Author	Alberto López-García
Author	Andreas Glenthøj
Author	Maria Gomes da Silva
Author	Caroline Besson
Author	Monia Marchetti
Author	Barbora Weinbergerová
Author	Ozren Jaksic
Author	Moraima Jiménez
Author	Yavuz M. Bilgin
Author	Jaap Van Doesum
Author	Francesca Farina
Author	Pavel Žák
Author	Luisa Verga
Author	Graham P. Collins
Author	Valentina Bonuomo
Author	Jens Van Praet
Author	Marcio Nucci
Author	Stef Meers
Author	Ildefonso Espigado
Author	Nicola S. Fracchiolla
Author	Toni Valković
Author	Christian Bjørn Poulsen
Author	Natasha Čolović
Author	Giulia Dragonetti
Author	Marie-Pierre Ledoux
Author	Carlo Tascini
Author	Caterina Buquicchio
Author	Ola Blennow
Author	Francesco Passamonti
Author	Marina Machado
Author	Jorge Labrador
Author	Rafael F. Duarte
Author	Martin Schönlein
Author	Lucia Prezioso
Author	Iker Falces-Romero
Author	Austin Kulasekararaj
Author	Carolina Garcia-Vidal
Author	Noemí Fernández
Author	Ghaith Abu-Zeinah
Author	Irati Ormazabal-Vélez
Author	Tatjana Adžić-Vukičević
Author	Klára Piukovics
Author	Igor Stoma
Author	Annarosa Cuccaro
Author	Gabriele Magliano
Author	Tomáš Szotkowski
Author	Tomás-José González-López
Author	Shaimaa El-Ashwah
Author	Rui Bergantim
Author	Uluhan Sili
Author	Johan Maertens
Author	Fatih Demirkan
Author	Cristina De Ramón
Author	Verena Petzer
Author	Maria Ilaria Del Principe
Author	Milan Navrátil
Author	Michelina Dargenio
Author	Guldane Cengiz Seval
Author	Michail Samarkos
Author	Zdeněk Ráčil
Author	László Imre Pinczés
Author	Tobias Lahmer
Author	Alessandro Busca
Author	Gustavo-Adolfo Méndez
Author	Antonio Vena
Author	Monika M. Biernat
Author	Maria Merelli
Author	Maria Calbacho
Author	Aleksandra Barać
Author	Martina Bavastro
Author	Alessandro Limongelli
Author	Osman Ilhan
Author	Dominik Wolf
Author	Gökçe Melis Çolak
Author	Ramón García-Sanz
Author	Ziad Emarah
Author	Bojana Mišković
Author	Stefanie K. Gräfe
Author	Miloš Mladenović
Author	Tommaso Francesco Aiello
Author	Lucía Núñez-Martín-Buitrago
Author	Anna Nordlander
Author	Elena Arellano
Author	Giovanni Paolo Maria Zambrotta
Author	Emanuele Ammatuna
Author	Alba Cabirta
Author	Maria Vittoria Sacchi
Author	Raquel Nunes Rodrigues
Author	Ditte Stampe Hersby
Author	Michaela Hanakova
Author	Laman Rahimli
Author	Raul Cordoba
Author	Oliver A. Cornely
Author	Livio Pagano
Author's institution	University of Rijeka Faculty of Health Studies
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract (english)	Objectives: Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail. Methods: We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy. Results: The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment. Conclusion: These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	International Journal of Infectious Diseases
Numbering	vol. 137, pp. 98-110
p-ISSN	1201-9712
DOI	https://doi.org/10.1016/j.ijid.2023.10.013
URN:NBN	urn:nbn:hr:184:069393
Publication	2023-12
Document URL	https://linkinghub.elsevier.com/retrieve/pii/S120197122300749X
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2024-02-26 09:30:31