Introduction: Sepsis represents a serious condition that arises as the body's response to infection and can lead to life-threatening complications. When sepsis is accompanied by circulatory, cellular, and metabolic dysfunctions, it progresses to septic shock, which further increases the risk of mortality. These conditions often result in high mortality rates and present a significant global health issue, especially among hospitalized patients. Objective: To assess the mortality rate from sepsis at the Intensive Care Unit of the Clinical Hospital Center Rijeka, with a specific focus on differences based on sex and age. Materials and Methods: The study was conducted through a retrospective review of medical records of patients diagnosed with sepsis who were hospitalized at KBC Rijeka in 2023. A total of 141 patients were included in the study, and the data were analyzed using descriptive statistics, including mean and standard deviation. Hypotheses were tested using the Chi-square test and Binomial test. Results: The mortality rate from sepsis in the intensive care units was 71.63%. The hypothesis of higher mortality in older patients (over 65 years) was confirmed, while differences in mortality between sexes were not statistically significant. The most common diagnoses were unspecified sepsis and other sepsis variants, while the most frequent causes of admission were abdominal pain and respiratory irregularities. Conclusion: Sepsis represents a serious public health issue with high mortality, especially among older patients. The study at the Clinical Hospital Center Rijeka confirms the high mortality rate from sepsis and underscores the critical role of nursing staff in the early detection and treatment of sepsis. The results highlight the need for improved approaches to sepsis treatment and providing adequate support to medical staff.