prikaz prve stranice dokumenta Perforin-mediated cytotoxicity in non-ST elevation myocardial infarction
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Scientific paper - Original scientific paper
Perforin-mediated cytotoxicity in non-ST elevation myocardial infarction
Scandinavian Journal of Immunology, 74 (2011), 2; 195-204. https://doi.org/10.1111/j.1365-3083.2011.02554.x
Laškarin, Gordana; Peršić, Viktor; Ružić, Alen; Miletić, Bojan; Rakić, Marijana; Samsa Travica, Dijana; Raljević, Damir; Pejčinović Pehar, Vesna; Miškulin, Rajko; Rukavina, Daniel

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Laškarin, G., Peršić, V., Ružić, A., Miletić, B., Rakić, M., Samsa Travica, D. ... Rukavina, D. (2011). Perforin-mediated cytotoxicity in non-ST elevation myocardial infarction. Scandinavian Journal of Immunology, 74. (2), 195-204. doi: 10.1111/j.1365-3083.2011.02554.x

Laškarin, Gordana, et al. "Perforin-mediated cytotoxicity in non-ST elevation myocardial infarction." Scandinavian Journal of Immunology, vol. 74, no. 2, 2011, pp. 195-204. https://doi.org/10.1111/j.1365-3083.2011.02554.x

Laškarin, Gordana, Viktor Peršić, Alen Ružić, Bojan Miletić, Marijana Rakić, Dijana Samsa Travica, Damir Raljević, Vesna Pejčinović Pehar, Rajko Miškulin and Daniel Rukavina. "Perforin-mediated cytotoxicity in non-ST elevation myocardial infarction." Scandinavian Journal of Immunology 74, no. 2 (2011): 195-204. https://doi.org/10.1111/j.1365-3083.2011.02554.x

Laškarin, G., et al. (2011) 'Perforin-mediated cytotoxicity in non-ST elevation myocardial infarction', Scandinavian Journal of Immunology, 74(2), pp. 195-204. doi: 10.1111/j.1365-3083.2011.02554.x

Laškarin G, Peršić V, Ružić A, Miletić B, Rakić M, Samsa Travica D, and sur.. Perforin-mediated cytotoxicity in non-ST elevation myocardial infarction. Scandinavian Journal of Immunology [Internet]. 2011 [cited 2025 February 07];74(2):195-204. doi: 10.1111/j.1365-3083.2011.02554.x

G. Laškarin, et al., "Perforin-mediated cytotoxicity in non-ST elevation myocardial infarction", Scandinavian Journal of Immunology, vol. 74, no. 2, pp. 195-204, 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:151314. [Accessed: 07 February 2025]

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Metadata
Title (english)Perforin-mediated cytotoxicity in non-ST elevation myocardial infarction
AuthorGordana Laškarin
AuthorViktor Peršić
AuthorAlen Ružić
AuthorBojan Miletić
AuthorMarijana Rakić
AuthorDijana Samsa Travica
AuthorDamir Raljević
AuthorVesna Pejčinović Pehar
AuthorRajko Miškulin
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Health Studies
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The aim of this investigation was to examine the role of perforin (P)-mediated cytotoxicity in the dynamics of tissue damage in patients with non-ST-segment elevation myocardial infarction (NSTEMI) treated with anti-ischaemic drugs. We enrolled 48 patients with NSTEMI in this study [age, 71.5 years; 61.5 ⁄ 76 (median, 25th ⁄ 75th percentiles)]. The percentage of total peripheral blood P+ lymphocytes was elevated owing to the increased frequency of P+ cells within natural killer (NK) subsets, T and NKT cells in patients on day 1 after NSTEMI when compared with healthy controls. Positive correlations were found between cardiac troponin I plasma concentrations and the frequency of P+ cells, P+ T cells, P+ NK cells and their CD56+dim and CD56+bright subsets during the first week after the NSTEMI. The expression of P in NK cells was accompanied by P-mediated cytotoxicity against K-562 targets at all days examined, except day 21, when an anti-perforin monoclonal antibody did not completely abolish the killing. The percentage of P+ T cells, P+ NKT cells and P+ NK subsets was the highest on the day 1 after NSTEMI and decreased in the post-infarction period. CD56+ lymphocytes were found in damaged myocardium, suggesting their tissue recruitment. In conclusion, patients with NSTEMI have a strong and prolonged P-mediated systemic inflammatory reaction, which may sustain autoaggressive reactions towards myocardial tissue during the development of myocardial infarction.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleScandinavian Journal of Immunology
Numberingvol. 74, no. 2, pp. 195-204
p-ISSN0300-9475
e-ISSN1365-3083
DOIhttps://doi.org/10.1111/j.1365-3083.2011.02554.x
URN:NBNurn:nbn:hr:184:151314
Publication2011
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-01-03 16:44:34