Uterine fibroids (lat. Myome Uteri) are the most common benign tumors of the uterus, composed of smooth muscle fibers (leiomyoma) and connective tissue (fibromyoma). When present, ultrasound shows an enlarged uterus with an irregular shape. The most commonly associated risk factors for the development of fibroids include hormonal imbalance between estrogen and progesterone, genetic factors, age, African ancestry, early menarche, late menopause, and parity. Additionally, other less common risk factors that contribute to fibroid formation include hypertension, polycystic ovary syndrome, excessive body weight, caffeine consumption, alcohol use, etc. In some cases, women are asymptomatic, but serious symptoms can occur that significantly affect quality of life, such as pelvic pain, frequent urination, painful intercourse, and heavy bleeding that occurs at irregular intervals, often leading to anemia. Furthermore, women of reproductive age have fibroids in 50 to 70% of cases, and they significantly affect fertility. Specifically, fibroids can disrupt the course of pregnancy, and in many cases, can prevent it. The impact depends on the number, size, and location of the fibroids. Anemia is a condition of reduced red blood cell volume in circulation, or decreased hemoglobin levels, resulting in a reduced ability of the blood to carry oxygen to tissues and organs. It manifests as feelings of increased fatigue, exhaustion, and poor concentration. The patient may exhibit pale skin and mucous membranes, tachycardia, hair loss, and even blood in the stool. Among patients with uterine fibroids, anemia occurs in more than 60% of cases. According to the WHO, quality of life is defined as an individual’s perception of their position in life in the context of their goals, expectations, and concerns. The aim of this research was to assess the quality of life in women diagnosed with uterine fibroids, considering pregnancy planning and the presence of anemia. The participants were women hospitalized at the Clinical Hospital Center Rijeka, at the Department of Gynecology and Obstetrics. The study involved 61 participants, and data was collected using the WHOQOL-BREF questionnaire, which was developed by the WHO to assess quality of life. Of the participants, 9 (14.75%) were planning a pregnancy, while 52 (85.25%) were not planning a pregnancy. 32 (52.46%) participants were diagnosed with anemia, while 29 (47.54%) did not have a diagnosis of anemia. After conducting the research, the results showed that there was no statistically significant difference in quality of life between the aforementioned groups.