Introduction: A stroke is caused by a sudden disruption of blood flow in the brain, which leads to an insufficient supply of certain parts of the brain with oxygen. The incidence of stroke is 1.45 times higher in the continental than in the coastal part of Croatia, which points to the important influence of lifestyle and environmental factors on the incidence of stroke. In many studies conducted in different countries around the world, a seasonally changing incidence of stroke is also reported. Objective: The main objective of this research is to examine the incidence of stroke in Karlovac County regarding the seasons. Methods: Retrospective analysis of data from the e-hit database for the period from January 1, 2017. until 31.12.2022. Results: 86% of the subjects had an ischemic stroke, and 14% of the subjects had a hemorrhagic stroke. In the period from 1.1.2017. until 31.12.2022. no statistically significant difference was found in the incidence of stroke according to the seasons. The highest number of strokes was diagnosed in the summer of 2017 and 2021, while the lowest number of strokes was in the winter of 2017 and spring of 2020. No statistically significant difference was found in the distribution of ischemic and hemorrhagic strokes during the seasons, and no statistically significant differences in the occurrence of strokes during the seasons in relation to the sex and age of the subjects were proven. Conclusion: The implementation of this research in the future can help guide public health interventions to reduce the number of cerebrovascular diseases and their consequences. The role of health workers, including nurses, is not only treatment and provision of health care, but also constant work on prevention and education of the population.