SUMMARY INTRODUCTION AND OBJECTIVE: Quality of life is a holistic concept and, above all, there is no concrete and clear definition for it. It encompasses various factors, including personal perception and evaluation of the concept. Coping strategies are the ways in which individuals interpret and solve problems, thereby influencing their daily functioning and their relationship with a neurologically at-risk child who requires adequate parental support. The objective of this research was to examine the relationship between parental coping strategies with stress and their perception of quality of life, considering their experience with neurodevelopmental treatment using the Vojta method in early intervention. PARTICIPANTS AND METHODS: There were 30 participants from the region of Slavonia whose children had a specific neuro-risk and were up to one year old, taking into account the corrected age of the children. Two validated questionnaires were used to investigate the coping strategies parents most commonly use and life satisfaction as a measure of their quality of life. The third questionnaire was designed by the author and consisted of additional questions to examine the perception of demands and parental stress when in the role of a therapist, and whether Vojta therapy affects their quality of life. RESULTS: The results have shown how parents use different coping strategies to deal with stress, which influence their perception of quality of life. Parents mostly use problem-focused coping strategy, which is positively correlated with life satisfaction (r=0.465; p<0.05), as well as avoidance coping strategy, which is also positively correlated with life satisfaction (r=0.470; p<0.05). The results indicate that younger parents are more likely to give up on Vojta method exercises (p<0.05). DISCUSSION AND CONCLUSION: Based on the obtained results, the first hypothesis was not confirmed. Coping strategies do influence the perception of quality of life. The second hypothesis was partially confirmed. Younger participants had a higher intention to give up on Vojta method exercises, thus confirming that the perception of demands and stressfulness of the parental role as a therapist is negatively correlated with their perception of quality of life, specifically in relation to their age; it negatively affects their perception of quality of life.