prikaz prve stranice dokumenta First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator
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Scientific paper - Original scientific paper
First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator
Diagnostics, 12 (2022), 3; 648. https://doi.org/10.3390/diagnostics12030648
Vojtusek, Ivana Kovacevic; Laganovic, Mario; Burek Kamenaric, Marija; Bulimbasic, Stela; Hrkac, Stela; Salai, Grgur; Ivković, Vanja; Coric, Marijana; Novak, Rudjer; Grgurevic, Lovorka

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Vojtusek, I. K., Laganovic, M., Burek Kamenaric, M., Bulimbasic, S., Hrkac, S., Salai, G. ... Grgurevic, L. (2022). First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator. Diagnostics, 12. (3). doi: 10.3390/diagnostics12030648

Vojtusek, Ivana Kovacevic, et al. "First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator." Diagnostics, vol. 12, no. 3, 2022. https://doi.org/10.3390/diagnostics12030648

Vojtusek, Ivana Kovacevic, Mario Laganovic, Marija Burek Kamenaric, Stela Bulimbasic, Stela Hrkac, Grgur Salai, Vanja Ivković, Marijana Coric, Rudjer Novak and Lovorka Grgurevic. "First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator." Diagnostics 12, no. 3 (2022). https://doi.org/10.3390/diagnostics12030648

Vojtusek, I. K., et al. (2022) 'First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator', Diagnostics, 12(3). doi: 10.3390/diagnostics12030648

Vojtusek IK, Laganovic M, Burek Kamenaric M, Bulimbasic S, Hrkac S, Salai G, and sur.. First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator. Diagnostics [Internet]. 2022 March 07 [cited 2024 December 26];12(3). doi: 10.3390/diagnostics12030648

I. K. Vojtusek, et al., "First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator", Diagnostics, vol. 12, no. 3, March 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:091633. [Accessed: 26 December 2024]

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Metadata
Title (english)First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator
AuthorIvana Kovacevic Vojtusek
AuthorMario Laganovic
AuthorMarija Burek Kamenaric
AuthorStela Bulimbasic
AuthorStela Hrkac
AuthorGrgur Salai
AuthorVanja Ivković
AuthorMarijana Coric
AuthorRudjer Novak
AuthorLovorka Grgurevic
Author's institutionUniversity of Rijeka
Faculty of Health Studies
(Department of Public Health)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background: We have previously shown that metzincin protease ADAMTS-4 accompanies renal fibrogenesis, as it appears in the blood of hemodialysis patients. Methods: Native kidney (NKB) and kidney transplant (TXCI) biopsy samples as well as plasma from patients with various stages of CKD were compared to controls. In paired analysis, 15 TXCI samples were compared with their zero-time biopsies (TX0). Tissues were evaluated and scored (interstitial fibrosis and tubular atrophy (IFTA) for NKB and Banff ci for TXCI). Immunohistochemical (IHC) staining for ADAMTS-4 and BMP-1 was performed. Plasma ADAMTS-4 was detected using ELISA. Results: ADAMTS-4 IHC expression was significantly higher in interstitial compartment (INT) of NKB and TXCI group in peritubular capillaries (PTC) and interstitial stroma (INT). Patients with higher stages of interstitial fibrosis (ci > 1 and IFTA > 1) expressed ADAMTS-4 in INT more frequently in both groups (p = 0.005; p = 0.013; respectively). In paired comparison, TXCI samples expressed ADAMTS-4 in INT and PTC more often than TX0. ADAMTS-4 plasma concentration varied significantly across CKD stages, being highest in CKD 2 and 3 compared to other groups (p = 0.0064). Hemodialysis patients had higher concentrations of ADAMTS-4 compared to peritoneal dialysis (p < 0.00001). Conclusion: ADAMTS-4 might have a significant role in CKD as a potential novel diagnostic indicator.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiagnostics
Numberingvol. 12, no. 3, 648
e-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics12030648
URN:NBNurn:nbn:hr:184:091633
Publication2022-03-07
Document URLhttps://www.mdpi.com/2075-4418/12/3/648
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-15 10:58:33