INTRODUCTION AND RESEARCH GOAL: Breast cancer and colon cancer are the main causes of mortality in Croatia, with special emphasis on late detection of breast cancer in women. National screening programs, such as mammography for women between the ages of 50 and 69, are key to early detection and increasing cure rates. Despite many years of implementation of these programs, the response is still low, which can be attributed to various factors such as unavailability of information and fear of diagnosis. This research is aimed at understanding the response of health professionals to the programs they promote themselves, and the reasons for their potential lack of response. RESPONDENTS AND METHODS: This cross-sectional quantitative research included 102 female respondents employed in public health institutions in the County of Istria, aged 50 to 72. It was conducted using a questionnaire with 13 questions, including sociodemographic data and personal history related to breast cancer. The survey questionnaire, created through a Google form, was sent by e-mail, and it took about 10 minutes to complete. The data were processed using Microsoft Excel and Statistica 14.0.0.15, while respecting the ethical principles and privacy of the respondents. RESULTS: The research showed a high response rate of 92.5% of health professionals who received an invitation for a mammography examination. The response rate was significantly higher than the average response rate of 60% in the general population of women in Croatia. The main reasons for non-response are practical reasons, such as acute illness, lack of information or work schedule. Suggestions for increasing the response rate were long-term health education and promotion, better information and advertising, and more flexible scheduling. CONCLUSION: Health workers in the County of Istria have a high response rate to the National Program for Early Detection of Breast Cancer, and among the reasons for non-response are practical reasons, lack of information and concern about the examination. These findings can be used to improve program response rates by addressing these issues and providing more information and support to those invited to participate.