prikaz prve stranice dokumenta Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit
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Scientific paper - Case study
Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit
Cureus Journal of Medical Science, 17 (2025), 2; e79164. https://doi.org/10.7759/cureus.79164
Miletić, Bojan; Schneiter, Simon; Lygkoni, Stavroula

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Miletić, B., Schneiter, S. & Lygkoni, S. (2025). Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit. Cureus Journal of Medical Science, 17. (2). doi: 10.7759/cureus.79164

Miletić, Bojan, et al. "Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit." Cureus Journal of Medical Science, vol. 17, no. 2, 2025. https://doi.org/10.7759/cureus.79164

Miletić, Bojan, Simon Schneiter and Stavroula Lygkoni. "Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit." Cureus Journal of Medical Science 17, no. 2 (2025). https://doi.org/10.7759/cureus.79164

Miletić, B., Schneiter, S. and Lygkoni, S. (2025) 'Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit', Cureus Journal of Medical Science, 17(2). doi: 10.7759/cureus.79164

Miletić B, Schneiter S, Lygkoni S. Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit. Cureus Journal of Medical Science [Internet]. 2025 February 17 [cited 2025 March 19];17(2). doi: 10.7759/cureus.79164

B. Miletić, S. Schneiter and S. Lygkoni, "Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit", Cureus Journal of Medical Science, vol. 17, no. 2, February 2025. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:880938. [Accessed: 19 March 2025]

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Metadata
Title (english)Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit
AuthorBojan Miletić
AuthorSimon Schneiter
AuthorStavroula Lygkoni
Author's institutionUniversity of Rijeka
Faculty of Health Studies
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Statin-induced necrotizing autoimmune myopathy (SINAM) is a rare but critical complication of statin therapy that leads to progressive muscle weakness. The complicated mechanisms underlying it make both diagnosis and treatment difficult. It is essential to recognize the condition early, especially in people who have had muscle problems treated with statins in the past. A 73-year-old woman arrived at the emergency department due to increasingly severe symmetrical muscle weakness accompanied by markedly elevated liver enzymes, creatine kinase (CK), and cardiac troponins. Although an acute cardiac event was ruled out, further tests indicated progressive myositis, necessitating hospitalization. A muscle biopsy subsequently confirmed myopathy with complement deposition, and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies were detected. With treatment that included corticosteroids, intravenous immunoglobulin, and rehabilitation, the patient showed remarkable improvement. This case undeniably highlights the critical importance of early detection of SINAM and intervention and emphasizes the absolute need for further research into causes and treatment strategies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCureus Journal of Medical Science
Numberingvol. 17, no. 2, e79164
e-ISSN2168-8184
DOIhttps://doi.org/10.7759/cureus.79164
URN:NBNurn:nbn:hr:184:880938
Publication2025-02-17
Document URLhttps://www.cureus.com/articles/343757-progressive-muscle-weakness-identifying-necrotizing-autoimmune-myopathy-as-a-rare-culprit?utm_medium=email&utm_source=transaction#!/
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2025-02-17 19:17:32