Sports injuries make the most of the injuries in the sport of the modern western society. Their treatment is rather demanding, expensive and takes a lot of time. Therefore, preventive measures are extremely important for both medical and economic reasons. Handball is a team and a contact sport characterized by fast play with frequent and sudden change of direction, interruptions and roughness on the field, all being the leading causes of injuries. Most of them are happening on training (60% of injuries), while the highest number of traumatic injuries are happening on the match. Although injuries are for the most part inevitable, proper preventive measures can decrease the risk of getting one. The participants of this research were the three sports clubs: the Croatian Premier League Club, the Macedonian First League Club and the Macedonian Euro League Club. By interviewing handball players and their expert’s teams, as well as viewing the clubs’ databases, it has been questioned do the mentioned sports clubs use preventive programs, in what way, what is the frequency of injuries and when and where do they happen. The obtained results were also compared to the results of the European and World Handball Federation’s research. The highest number of injuries engages the lower extremity (47,3%) and the most frequent injury of lower extremity is the injury of an ankle joint. Having in mind that the majority of injuries happen on training the attention should be directed towards the education of expert’s team so that they include preventive measures in everyday training. When it comes to the match, an enhanced supervision and stricter penalties should be established in order to avoid injuries which players sometimes cause intentionally during contact.