Inhaled nitric oxide is the most commonly used analgesic during childbirth in many countries, and it is becoming increasingly popular in Croatia. Nitrous oxide is a colorless, almost odorless and tasteless gas used for inhalation to provide analgesia during painful procedures. Nitrous oxide is safe for both mother and baby and is an acceptable alternative for analgesia in all stages of labor and/or postpartum procedures. A number of women described their experience with nitrous oxide as being consistent with their birth plan and were satisfied. Parturients reported non-analgesic benefits of using nitrous oxide (relaxation, distraction, focus on breathing), as well as partial analgesic effects that they considered sufficient or in line with their expectations. The vast majority of women taking nitrous oxide for pain report high satisfaction with labor despite variable analgesia effectiveness, although studies show that labor pain, per se, is not the only predictor of satisfaction with the birth experience. With the increasingly widespread use of nitrous oxide during childbirth in some countries and the growing interest in this method in Croatia, after a systematic search of the literature to find relevant articles on this topic, we examined the level of pain in labor before and after the use of nitrous oxide, as well as the relationship with satisfaction with childbirth with variables related to the person, birth and child, all in order to get answers to the questions that determined the goals of this work.