In recent decades, with the development of medicine, the installation of implants is increasing in various fields, especially in orthopedics. Orthopedic implants have contributed to better mobility and reduced joint pain for millions of people around the world. Infection after knee endoprosthesis as a complication is associated with higher treatment costs, prolonged hospital stay, and has proven to increase patient morbidity and mortality. There are numerous risk factors for the development of surgical site infections, such as: age, obesity, the presence of distant infections in other parts of the body, extended preoperative stay, shaving with a razor, extended duration of surgery, failure to apply antibiotic prophylaxis. Healthcare workers can have a preventive effect on most factors and prevent the development of hospital infection. Monitoring surgical wound infections is an important part of the strategy to reduce the incidence of infections and improve patient safety. The aim of this paper is to determine whether there is a difference in the incidence of hospital-acquired infections after total knee arthroplasty with regard to gender and age, and to determine the relationship between the occurrence of hospital-acquired infections after total knee arthroplasty and the length of the patient's hospitalization and diabetes mellitus. All patients after total knee arthroplasty were included. The data analysis covers a five-year period. In the conducted research, age and gender are not statistically significant and are not indicators of a high risk of infection. No statistically significant data was found on the increase in the incidence of infection in hospitalizations longer than 14 days, and diabetes mellitus was not a relevant risk factor for the occurrence of infection after knee endoprosthesis in the conducted research.