Introduction: Asthma is an inflammatory disease of the small airways that is manifested by difficulty breathing, lack of air, coughing, tightness in the chest and wheezing. We distinguish several degrees of asthma from intermittent asthma to severe permanent asthma. Standard asthma therapy usually includes short-acting and long-acting β-agonists and corticosteroids. In patients with severe asthma who, despite maximum therapy, still do not achieve good disease control, biological therapy is introduced. Biologic therapy involves the use of genetically modified proteins or antibodies to specifically affect certain components of the immune system that are responsible for the inflammation present in asthma. Aim: To compare the status of asthma control (compare FEV1, FVC and FEV1/FVC values and data from the asthma control questionnaire: ACT (Asthma control test) and ACQ (Asthma control questionnaire) between the group of patients on standard therapy and the group of patients on biological therapy. Subjects and methods: 40 patients diagnosed with severe asthma were divided into two groups: 1) treated with standard therapy (n= 20), and 2) treated with biological therapy (n= 20). The measuring instruments used during data collection are spirometry values and questionnaires for the assessment of asthma control ACT and ACQ. Results: When comparing FVC (L) values between the groups of subjects on standard therapy and those on biological therapy, a statistically significant difference was found, and the values of FVC (L) were significantly higher in the group of subjects on biological therapy. Also, when comparing the FEV1(L) values, a significant difference was found, and the FEV1(L) values were significantly higher in subjects on biological therapy. When comparing the values of the FEV1/FVC ratio (%), no statistically significant difference was found between the groups. The comparison of ACQ values between groups establishes a statistically significant difference and shows that the group on biological therapy has better asthma control. Also, when comparing the ACT values between the two groups, a significant difference was found, which shows that the group on biological therapy has better asthma control. Conclusion: The obtained results indicate that patients treated with biological therapy have better disease control than patients treated with standard therapy.