Introduction: Today soccer is considered one of the most popular sports, it is characterized as a highly intensed activity where because of dynamic and explosive movements injuries occur very often. Because of all mentioned, leading soccer organization published their own program called FIFA 11+, the exercises from the program works the best for the core stability, balance and strength. In other word, it has influence on all the abilities which are important to prevent the risk of possible injuries. Objectives: The goal of the research is to analyze the influence of the FIFA 11+ prevention program on the balance and isometric strength of knee joint extensor muscles which makes m. quadriceps femoris, because of big influence of this segments on the risk of injuries in soccer players. Subjects and methods: Subjects of the research were 25 soccer players from the Soccer team „Orijent“. They belong in the senior group from 18 till 35 years old. The research was held in the club premises of „Orijent“, at the stadium „Krimeja“. Firstly, balance measurements were carried out using a simple y – balance test. Then we also get measurements of isometric strength of knee extensor muscles with the help of a portable fixed dynamometer EasyForce, device of company Meloq AB, Sweden. After first measurements, for 14 days FIFA 11+ preventive program was carried out, the exercises in the program includes various running exercises, strength exercises, balance and plyometric exercises. After the program, the measurements were repeated in the same conditions like first time. Results: Findings from this research in the sense of measuring balance while using the y – balance test, have shown how there is a statistically significant difference in all directions from both legs, except when the left leg moves in the posterolateral direction. Moreover, measuring isometric strength of knee extensor muscles there is a significant statistical difference increase of the average force or average strength. While studying peak force of the knee joint extensor muscles, there is no statistically significant difference. Conclusion: Research has shown that the FIFA 11+ preventive program in short term period has an effect on balance and isometric strength of the knee extensors. Additionaly, this research aims to increase the level of information about prevention of football player injuries, which are not lacking due to the efforts of athletes.