Introduction: The transition to motherhood represents a process of adjustment during which women face physical, psychological, and social changes, often leading to stress that can increase the risk of postpartum depression (PPD). In this context, continuous professional support and prenatal education, such as home visits by patronage nurses and prenatal classes, can help alleviate this stress and facilitate the transition to motherhood. Aim: To examine the level of postpartum stress among mothers and assess perceived support from patronage nurses. Participants and methods: The research was conducted using an online questionnaire on a convenient sample of 389 mothers within the first year after childbirth. Questionnaires measuring postpartum stress and perceived support from patronage nurses were used. Results: Statistical analysis tested three hypotheses. A weak negative correlation was found between postpartum stress and perceived support from patronage nurses, highlighting the importance of continuous support from this healthcare profession. However, no statistically significant difference in postpartum stress levels was observed between primiparous and multiparous mothers, nor between mothers who attended prenatal classes and those who did not. Conclusion: The results of this research highlight the important role of patronage nurses in providing support to mothers to alleviate postpartum stress. Moreover, further research is needed to develop effective interventions and gain a better understanding of the complex experience of motherhood.