Turner’s syndrome, also known as congenital ovarian hypoplasia was first described in 1938 by doctor Henry Turner, in Oklahoma, Texas. The syndrome is defined as a chromosomopathy with complete or partial monosomy of chromosome X which occurs in a female and it is related to one or more clinical manifestations. In average, Turner’s syndrome appears to occur in approximately 1 in 2000 to 1 in 2500 newborns, which is around 0.04 – 0.05 %. Prenatally, it is diagnosed by amniocentesis or by sampling chorionic villi, and postnatally by a genetic karyotyping test. The most common clinical signs are significant growth deficit, the absence of secondary sexual characteristics, among many other symptoms, including musculoskeletal and cardiovascular malformations and the lack of cognitive functionality in the area of social and psychomotor skills as the most often cases. The treatment depends on the symptoms and can include operational techniques due to heart malformations, along with mandatory hormone replacement therapy by growth hormone to stimulate growth and exogenous estrogen replacement due to lack of secondary sexual characteristics. Hormone replacement therapy extends the lifetime expectancy to the one of an average healthy person, but comes with increased risk of osteporosis and osteopenia, higher blood pressure, obesity, diabetes and other diseases and symptoms that significantly affect the quality of life. There are five categories upon which main guidelines were created for medical treatment of a patient with Turner’s syndrome : diagnostic and genetic issues, growth and development during childhood and adolescence, congenital and acquired cardiovascular diseases, adult care and neurocognitive issues. Every patient requires an individual approach provided by a multidisciplinary team in which the physiotherapist, following the comprehensive plan, bases the goal of implementing the physiotherapeutic procedure on the basis of complications of drug-induced growth and development, osteporosis and osteopenia as well as congenital musculoskeletal and cardiovascular malformations, assuring the quality and confidential collaboration with the patient and the team. Interprofessional approach of a multidisciplinary team and the adequate collaboration with a patient will lead to desired and optimal outcomes in the treatment and rehabilitation of a patient with Turner’s syndrome.