This study is a quantitative, randomized study to examine the quality of pain and strength in patients with radial epicondylitis. Radial epicondylitis is characterized by pain and swelling in the local area of tendons and tendon insertions that are inserted on the lateral epicondyle of the humerus. The pain is usually localized on the external part of the elbow and make movements, such as a hand grip, difficult. The study used validated tests. The visual analog scale (VAS) is used to examine the intensity of pain, and manual muscle test (MMT) for muscle strength evaluation. Initial and final evaluation were conducted by qualified team members. This study examined the effect of osteopathic manual therapy compared to physiotherapy treatment on pain and strength in people with radial epicondylitis of the humerus. The sample consisted of 16 subjects, 30-60 years old, and diagnosed with lateral epicondylitis by a medical specialist. 8 subjects were selected into experimental and 8 patients in the control group. To test pain intensity visual analog scale (VAS) was used, and manual muscle test (MMT) for the assessment of muscle strength was applied. For data analysis, measures of descriptive statistics (mean and standard deviation) were used. The original results of both measurements of the manual muscle test were transformed into the percentage form of scale maximum (% SM). To compare results between two groups (experimental and control) a test for two independent samples, Mann-Whitney U test, was used. This test is expressed with a difference in p value. A comparison of results between the two measurements for each group separately underwent a test for dependent samples, Wilcoxon Signed Ranks Test, which aklso gives a p value.. The results are presented in tables and graphs (histogram). The obtained statistical results of this study showed that in the test quality of pain by the VAS scale there was no statistically significant difference between groups. There was a statistically significant difference in terms of significantly lower values for estimated pain in the second measurement for both the experimental and control groups. Measuring muscle strength by manual muscle test did not reveal statistically significant differences between groups. In the experimental group, all three manual muscle tests demonstrated statistically significant difference between the first and final measurements in terms of significantly higher values in the second measurements, indicating a positive therapeutic effect of osteopathy. In the control group, all three manual muscle tests demonstrated a statistically significant difference between the first and final measurements in terms of significantly higher values in the second measurement indicating a positive therapeutic effect of physiotherapy. Based on the statistical results, our research shows that the osteopathic treatment for the reduction of pain and increase in muscle strength in patirents with lateral epicondylitis had no significantly greater effect than did standard physiotherapy treatment. Both showed statistically significant improvement in pain decrease and strength with treatment. The fact that the osteopathy results were, at least comparable, to the physiotherapy results shows that physiotherapy and osteopathy is a valid treatment method for the treatment of lateral epicondylitis and has a place in the health care system and can be considered a complementary therapeutic approach.