prikaz prve stranice dokumenta Green solvent-free synthesis of new N-heterocycle-L-ascorbic acid hybrids and their antiproliferative evaluation
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Green solvent-free synthesis of new N-heterocycle-L-ascorbic acid hybrids and their antiproliferative evaluation
Future Med. Chem., 14 (2022), 16; 1187-1202. https://doi.org/10.4155/fmc-2022-0047
Bistrović Popov, Andrea; Meščić Macan, Andrijana; Jakopec, Silvio; Prpi´c, Helena; Harej Hrkać, Anja; Kraljeviić Pavelić, Sandra; Raić-Malić, Silvana

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Bistrović Popov, A., Meščić Macan, A., Jakopec, S., Prpi´c, H., Harej Hrkać, A., Kraljeviić Pavelić, S. i Raić Malić, S. (2022). Green solvent-free synthesis of new N-heterocycle-L-ascorbic acid hybrids and their antiproliferative evaluation. Future Med. Chem., 14. (16), 1187-1202. doi: 10.4155/fmc-2022-0047

Bistrović Popov, Andrea, et al. "Green solvent-free synthesis of new N-heterocycle-L-ascorbic acid hybrids and their antiproliferative evaluation." Future Med. Chem., vol. 14, br. 16, 2022, str. 1187-1202. https://doi.org/10.4155/fmc-2022-0047

Bistrović Popov, Andrea, Andrijana Meščić Macan, Silvio Jakopec, Helena Prpi´c, Anja Harej Hrkać, Sandra Kraljeviić Pavelić i Silvana Raić Malić. "Green solvent-free synthesis of new N-heterocycle-L-ascorbic acid hybrids and their antiproliferative evaluation." Future Med. Chem. 14, br. 16 (2022): 1187-1202. https://doi.org/10.4155/fmc-2022-0047

Bistrović Popov, A., et al. (2022) 'Green solvent-free synthesis of new N-heterocycle-L-ascorbic acid hybrids and their antiproliferative evaluation', Future Med. Chem., 14(16), str. 1187-1202. doi: 10.4155/fmc-2022-0047

Bistrović Popov A, Meščić Macan A, Jakopec S, Prpi´c H, Harej Hrkać A, Kraljeviić Pavelić S, i sur.. Green solvent-free synthesis of new N-heterocycle-L-ascorbic acid hybrids and their antiproliferative evaluation. Future Med. Chem. [Internet]. 2022. [pristupljeno 10.11.2024.];14(16):1187-1202. doi: 10.4155/fmc-2022-0047

A. Bistrović Popov, et al., "Green solvent-free synthesis of new N-heterocycle-L-ascorbic acid hybrids and their antiproliferative evaluation", Future Med. Chem., vol. 14, br. 16, str. 1187-1202, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:144906. [Citirano: 10.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:144906
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Naslov (engleski)Green solvent-free synthesis of new N-heterocycle-L-ascorbic acid hybrids and their antiproliferative evaluation
AutorAndrea Bistrović Popov
AutorAndrijana Meščić Macan
AutorSilvio Jakopec
AutorHelena Prpi´c
AutorAnja Harej Hrkać
AutorSandra Kraljeviić Pavelić
AutorSilvana Raić-Malić
Autorova ustanovaSveučilište u Rijeci
Fakultet zdravstvenih studija
(Katedra za temeljne medicinske znanosti)
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Biotehnologija
Molekularna biotehnologija
Sažetak (engleski)
The authors’ aim was to improve the application of copper-catalyzed azide-alkyne cycloaddition in the synthesis of hybrids containing biologically significant nucleobases and L-ascorbic acid scaffolds by introducing an environmentally friendly and waste-free ball mill. Results: Two series of hybrids with a purine, pyrrolo[2,3-d]pyrimidine or 5-substituted pyrimidine attached to 2,3-dibenzyl-L-ascorbic acid via a hydroxyethyl- (15a–23a) or ethylidene-1,2,3-triazolyl (15b–23b) bridge were prepared by ball milling and conventional synthesis. The unsaturated 6-chloroadenine L-ascorbic acid derivative 16b can be highlighted as a lead compound and showed strong antiproliferative activity against HepG2 (hepatocellular carcinoma) and SW620 (colorectal adenocarcinoma) cells. Conclusion: Mechanochemical synthesis was superior in terms of sustainability, reaction rate and yield, highlighting the advantageous applications of ball milling over classical reactions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFuture Med. Chem.
Brojčani podacivol. 14, br. 16, str. 1187-1202
p-ISSN1756-8919
DOIhttps://doi.org/10.4155/fmc-2022-0047
URN:NBNurn:nbn:hr:184:144906
Datum objave publikacije2022
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-01-30 13:26:12