The quality of life of institutionalized persons with disabilities is a complex and often challenging topic that requires careful consideration and analysis. Institutionalization refers to the placement of people with disabilities in specialized institutions or group homes for care and support. The quality of life of institutionalized persons with disabilities depends on a number of factors, including access to resources, rights, support and their living environment. It is essential that society and institutions continuously work to improve these aspects to ensure that these people can lead fulfilling and satisfying lives despite their disabilities. The aim of this research work is to determine whether there is a difference in attitudes about the quality of life of institutionalized persons with disabilities between students of the first and third year of the regular undergraduate professional study of Nursing, and to determine whether there is a difference in attitudes about the quality of life of institutionalized persons with disabilities between students. The research included full-time first- and second-year undergraduate professional nursing students who filled out an anonymous survey. The results indicate positive attitudes with good knowledge of the quality of life of institutionalized persons with disabilities. Also, the respondents of both years, regardless of completed secondary medical school or gymnasium, showed knowledge in terms of institutionalization and disability.