prikaz prve stranice dokumenta First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator
  Preuzmi
PDF 2.33 MB
Znanstveni rad - Izvorni znanstveni rad
First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator
Diagnostics, 12 (2022), 3; 648. https://doi.org/10.3390/diagnostics12030648
Vojtusek, Ivana Kovacevic; Laganovic, Mario; Burek Kamenaric, Marija; Bulimbasic, Stela; Hrkac, Stela; Salai, Grgur; Ivković, Vanja; Coric, Marijana; Novak, Rudjer; Grgurevic, Lovorka

Citirajte ovaj rad

Vojtusek, I. K., Laganovic, M., Burek Kamenaric, M., Bulimbasic, S., Hrkac, S., Salai, G. ... Grgurevic, L. (2022). First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator. Diagnostics, 12. (3). doi: 10.3390/diagnostics12030648

Vojtusek, Ivana Kovacevic, et al. "First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator." Diagnostics, vol. 12, br. 3, 2022. https://doi.org/10.3390/diagnostics12030648

Vojtusek, Ivana Kovacevic, Mario Laganovic, Marija Burek Kamenaric, Stela Bulimbasic, Stela Hrkac, Grgur Salai, Vanja Ivković, Marijana Coric, Rudjer Novak i Lovorka Grgurevic. "First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator." Diagnostics 12, br. 3 (2022). https://doi.org/10.3390/diagnostics12030648

Vojtusek, I. K., et al. (2022) 'First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator', Diagnostics, 12(3). doi: 10.3390/diagnostics12030648

Vojtusek IK, Laganovic M, Burek Kamenaric M, Bulimbasic S, Hrkac S, Salai G, i sur.. First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator. Diagnostics [Internet]. 07.03.2022. [pristupljeno 05.05.2024.];12(3). doi: 10.3390/diagnostics12030648

I. K. Vojtusek, et al., "First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator", Diagnostics, vol. 12, br. 3, Ožujak 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:091633. [Citirano: 05.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:091633
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)First Characterization of ADAMTS-4 in Kidney Tissue and Plasma of Patients with Chronic Kidney Disease—A Potential Novel Diagnostic Indicator
AutorIvana Kovacevic Vojtusek
AutorMario Laganovic
AutorMarija Burek Kamenaric
AutorStela Bulimbasic
AutorStela Hrkac
AutorGrgur Salai
AutorVanja Ivković
AutorMarijana Coric
AutorRudjer Novak
AutorLovorka Grgurevic
Autorova ustanovaSveučilište u Rijeci
Fakultet zdravstvenih studija
(Katedra za javno zdravstvo)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Background: We have previously shown that metzincin protease ADAMTS-4 accompanies renal fibrogenesis, as it appears in the blood of hemodialysis patients. Methods: Native kidney (NKB) and kidney transplant (TXCI) biopsy samples as well as plasma from patients with various stages of CKD were compared to controls. In paired analysis, 15 TXCI samples were compared with their zero-time biopsies (TX0). Tissues were evaluated and scored (interstitial fibrosis and tubular atrophy (IFTA) for NKB and Banff ci for TXCI). Immunohistochemical (IHC) staining for ADAMTS-4 and BMP-1 was performed. Plasma ADAMTS-4 was detected using ELISA. Results: ADAMTS-4 IHC expression was significantly higher in interstitial compartment (INT) of NKB and TXCI group in peritubular capillaries (PTC) and interstitial stroma (INT). Patients with higher stages of interstitial fibrosis (ci > 1 and IFTA > 1) expressed ADAMTS-4 in INT more frequently in both groups (p = 0.005; p = 0.013; respectively). In paired comparison, TXCI samples expressed ADAMTS-4 in INT and PTC more often than TX0. ADAMTS-4 plasma concentration varied significantly across CKD stages, being highest in CKD 2 and 3 compared to other groups (p = 0.0064). Hemodialysis patients had higher concentrations of ADAMTS-4 compared to peritoneal dialysis (p < 0.00001). Conclusion: ADAMTS-4 might have a significant role in CKD as a potential novel diagnostic indicator.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDiagnostics
Brojčani podacivol. 12, br. 3, 648
e-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics12030648
URN:NBNurn:nbn:hr:184:091633
Datum objave publikacije2022-03-07
URL dokumentahttps://www.mdpi.com/2075-4418/12/3/648
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-01-15 10:58:33