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Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis
Acta clinica Croatica, 61. (2022), 2; 311-319. https://doi.org/10.20471/acc.2022.61.02.18
Vukelić, Jelena; Dobrila-Dintinjana, Renata; Marijić, Blažen; Maržić, Diana; Braut, Tamara

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Vukelić, J., Dobrila Dintinjana, R., Marijić, B., Maržić, D. i Braut, T. (2022). Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis. Acta clinica Croatica, 61.. (2), 311-319. doi: 10.20471/acc.2022.61.02.18

Vukelić, Jelena, et al. "Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis." Acta clinica Croatica, vol. 61., br. 2, 2022, str. 311-319. https://doi.org/10.20471/acc.2022.61.02.18

Vukelić, Jelena, Renata Dobrila Dintinjana, Blažen Marijić, Diana Maržić i Tamara Braut. "Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis." Acta clinica Croatica 61., br. 2 (2022): 311-319. https://doi.org/10.20471/acc.2022.61.02.18

Vukelić, J., et al. (2022) 'Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis', Acta clinica Croatica, 61.(2), str. 311-319. doi: 10.20471/acc.2022.61.02.18

Vukelić J, Dobrila Dintinjana R, Marijić B, Maržić D, Braut T. Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis. Acta clinica Croatica [Internet]. 2022. [pristupljeno 23.12.2024.];61.(2):311-319. doi: 10.20471/acc.2022.61.02.18

J. Vukelić, R. Dobrila Dintinjana, B. Marijić, D. Maržić i T. Braut, "Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis", Acta clinica Croatica, vol. 61., br. 2, str. 311-319, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:251964. [Citirano: 23.12.2024.]

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Podaci o radu
Naslov (engleski)Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis
Naslov (hrvatski)Klinički tijek bolesti i ishod liječenja kod bolesnika s malignim tumorima grkljana: retrospektivna petogodišnja analiza
AutorJelena Vukelić https://orcid.org/0000-0001-5828-9087
AutorRenata Dobrila-Dintinjana
AutorBlažen Marijić https://orcid.org/0000-0001-6094-7114
AutorDiana Maržić
AutorTamara Braut
Autorova ustanovaSveučilište u Rijeci
Fakultet zdravstvenih studija
(Katedra za kliničke medicinske znanosti II)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Otorinolaringologija
Sažetak (engleski)
The aim was to investigate clinical course of disease in patients with malignant laryngeal tumors with emphasis on various forms of disease recurrence (local recurrence, metastasis to regional lymph nodes, occurrence of second primary tumor). A retrospective research including 78 patients with histopathologically confirmed diagnosis of squamous cell laryngeal carcinoma was conducted. Information on cancer stage, histologic grade, type of treatment and disease recurrence was obtained from medical history. Tissue samples of the patients were submitted to immunohistochemical analysis and assessment of Ki-67 proliferation index expression. The occurrence of second primary tumor was found to be related to the significantly higher Ki-67 proliferation index. The number of patients having not undergone oncologic therapy and remained free from disease recurrence was significantly higher than expected. Treatment outcome depends on patient age, histologic grade, radiotherapy applied, and clinical course of disease. It is necessary to define the predictive factors of various forms of disease recurrence more precisely in order to identify better treatment options for patients with malignant tumors of the larynx.
Sažetak (hrvatski)
Cilj je bio istražiti klinički tijek bolesti kod bolesnika sa zloćudnim tumorima grkljana s osvrtom na razne oblike povrata bolesti (lokalni recidiv, metastaze u regionalne limfne čvorove, pojavnost drugog primarnog tumora). Proveli smo retrospektivno istraživanje na 78 bolesnika s patohistološki potvrđenom dijagnozom planocelularnog karcinoma grkljana. Iz povijesti bolesti dobili smo podatke o stadiju karcinoma, histološkom gradusu, vrsti provedenog liječenja te o povratu bolesti. Na patohistološkim uzorcima tkiva tih bolesnika učinili smo imunohistokemijsku analizu i procjenu ekspresije proliferacijskog čimbenika Ki-67. Pojava drugog primarnog tumora vezana je uz značajno veći proliferacijski indeks Ki-67. Značajno veći je bio udio bolesnika kod kojih nije provedena onkološka terapija, a koji naknadno nisu razvili neki od oblika povrata bolesti. Ishod liječenja ovisi o dobi bolesnika, histološkom gradusu, primijenjenoj radioterapiji i kliničkom tijeku bolesti. Potrebno je preciznije definirati prediktivne čimbenike rizika za razne oblike povrata bolesti kako bismo bolje i kvalitetnije liječili bolesnike s malignim tumorima grkljana.
Ključne riječi (engleski)
Ključne riječi (hrvatski)
Jezikengleski
Jezikhrvatski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa clinica Croatica
Brojčani podacivol. 61., br. 2, str. 311-319
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2022.61.02.18
URN:NBNurn:nbn:hr:184:251964
Datum objave publikacije2022
URL dokumentahttps://hrcak.srce.hr/285011
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-01-15 12:45:01