HPV infection is the most common sexually transmitted infection. More than 200 virus genotypes have been identified, where we distinguish between high-risk and oncogenic ones (type 16 and 18) and low-risk ones (type 6 and 11). There are risk factors for a HPV infection, such as early sexual intercourse, unprotected sex, promiscuous behavior, drug and alcohol abuse. In most cases, the infection is asymptomatic and does not require treatment. The most common site of infection is the skin, followed by the urinary system, genitals, trachea, esophagus and buccal mucosa. Statistical data from the HZJZ show that more than 80% of the sexually active population is infected with HPV. Prevention includes education, vaccination and early screening for cervical cancer. The Pap smear is the gold standard in detecting HPV infections. The treatment of the infection depends on the severity of the disease and the symptoms. This research showed the knowledge of students about HPV infection in secondary schools with regard to the direction of the school they attend, the gender of the students and how much they have been educated about HPV so far. It was found that women have more knowledge about HPV than men. A difference in knowledge was also found between students of secondary medical school and gymnasium. The students of the medical school had a higher level of knowledge. More than 73% of students have been educated about HPV so far, but regardless of education, the largest number of respondents had 5 points on the knowledge test out of a maximum of 10.