prikaz prve stranice dokumenta Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit
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Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit
Cureus Journal of Medical Science, 17 (2025), 2; e79164. https://doi.org/10.7759/cureus.79164
Miletić, Bojan; Schneiter, Simon; Lygkoni, Stavroula

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Miletić, B., Schneiter, S. i Lygkoni, S. (2025). Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit. Cureus Journal of Medical Science, 17. (2). doi: 10.7759/cureus.79164

Miletić, Bojan, et al. "Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit." Cureus Journal of Medical Science, vol. 17, br. 2, 2025. https://doi.org/10.7759/cureus.79164

Miletić, Bojan, Simon Schneiter i Stavroula Lygkoni. "Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit." Cureus Journal of Medical Science 17, br. 2 (2025). https://doi.org/10.7759/cureus.79164

Miletić, B., Schneiter, S. i Lygkoni, S. (2025) 'Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit', Cureus Journal of Medical Science, 17(2). doi: 10.7759/cureus.79164

Miletić B, Schneiter S, Lygkoni S. Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit. Cureus Journal of Medical Science [Internet]. 17.02.2025. [pristupljeno 25.02.2025.];17(2). doi: 10.7759/cureus.79164

B. Miletić, S. Schneiter i S. Lygkoni, "Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit", Cureus Journal of Medical Science, vol. 17, br. 2, Veljača 2025. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:880938. [Citirano: 25.02.2025.]

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Podaci o radu
Naslov (engleski)Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit
AutorBojan Miletić
AutorSimon Schneiter
AutorStavroula Lygkoni
Autorova ustanovaSveučilište u Rijeci
Fakultet zdravstvenih studija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Statin-induced necrotizing autoimmune myopathy (SINAM) is a rare but critical complication of statin therapy that leads to progressive muscle weakness. The complicated mechanisms underlying it make both diagnosis and treatment difficult. It is essential to recognize the condition early, especially in people who have had muscle problems treated with statins in the past. A 73-year-old woman arrived at the emergency department due to increasingly severe symmetrical muscle weakness accompanied by markedly elevated liver enzymes, creatine kinase (CK), and cardiac troponins. Although an acute cardiac event was ruled out, further tests indicated progressive myositis, necessitating hospitalization. A muscle biopsy subsequently confirmed myopathy with complement deposition, and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies were detected. With treatment that included corticosteroids, intravenous immunoglobulin, and rehabilitation, the patient showed remarkable improvement. This case undeniably highlights the critical importance of early detection of SINAM and intervention and emphasizes the absolute need for further research into causes and treatment strategies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prikaz slučaja
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCureus Journal of Medical Science
Brojčani podacivol. 17, br. 2, e79164
e-ISSN2168-8184
DOIhttps://doi.org/10.7759/cureus.79164
URN:NBNurn:nbn:hr:184:880938
Datum objave publikacije2025-02-17
URL dokumentahttps://www.cureus.com/articles/343757-progressive-muscle-weakness-identifying-necrotizing-autoimmune-myopathy-as-a-rare-culprit?utm_medium=email&utm_source=transaction#!/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2025-02-17 19:17:32