Multiple Sclerosis (MS) is a chronic, autoimmune, demyelinating disease that affects the young adult population and leads to neurological deficits that undermine the quality of everyday life. During the illness a variety of symptoms appear, but the most severe consequences come from physical disability. Functional tests to evaluate different aspects of everyday life (physical, emotional, cognitive and psychosocial) individuals with MS physiotherapists can get a better insight into their current health condition and thus have easier access to rehabilitation. The primary goal of this research is to point to the importance of reducing the quality of life due to reduced physical functionality and independence in MS patients, thereby contributing to a faster and more consistent involvement in the rehabilitation program of therapeutic exercise and other treatments. The secondary goal is to point to the importance and practicality of the application of functional tests to detect the primary goal. The results showed that there was a statistically significant difference in the lack of physical functionality and independence and increased physical limitation in MS patients compared to non-obese patients. The lack of physical functionality in MS patients statistically significantly reduces the quality of general health and psychosocial function and increases physical dependence on others, but does not significantly affect emotional health. It can be concluded that due to the lack of physical functionalities the quality of life is disturbed in MS patients compared to the non-disabled, including the general and psychosocial aspects of everyday life. We can also conclude that the application of functional tests facilitates physiotherapeutic assessment of the condition and access to MS patients when planning rehabilitation.