Introduction and Aim: Juvenile idiopathic arthritis (JIA) is a chronic inflammatory rheumatic disease of childhood. It occurs prior to 16 years of age and is characterized by inflammation of one or more joints lasting longer than 6 weeks. As far as chronic illness is concerned, it can greatly affect the quality of life of a child. The aim of the paper was to determine whether there are differences in the self-assessment of the quality of life of children suffering from JIA treated at the Pediatric Clinic of KBC Rijeka in relation to healthy peers attending »Kantrida« Elementary School. Also, one of the goals of the paper was to determine whether there is a statistically significant difference between the response of children and their parents' answers to questions related to quality of life. Participants and Methods: The study was conducted on 60 persons (30 children and 30 parents). The study group consists of children (13 participants) aged 8 to 14 treated at the Pediatric Clinic of KBC Rijeka and their parents/guardians (13 participants). The control group consists of children from »Kantrida« Elementary School (17 participants) and their parents (17 participants). The study was conducted by using the PedsQL questionnaire. Results: Research has provided data indicating that there is no statistically significant difference between the response of children and the response of their parents to both questionnaires. Comparison of overall quality of life between JIA and control group revealed statistically significant differences in physical health (p = 0.004), school activities (p = 0.004), psychosocial health (p = 0.01) and total overall health (p = 0.012) between JIA and the control group. There was no statistically significant difference in emotional health and social activity (p = 0.229 and p = 0.057). Comparison of the response from the rheumatological questionnaire revealed a statistically significant difference in the quality of life of rheumatic patients in relation with pain (p = 0.01), daily activities (p = 0.02), treatment of rheumatic disease (p = 0.01), concern (p<0.001) and communication about its disease (p <0.001) between JIA and control group. Conclusion: Research findings suggest that JIA affects the quality of life of the affected. There is no statistically significant difference between the response of children and the response of their parents to both questionnaires.