Peripheral arterial disease (PAD) is a vascular disease that results in the narrowing or blockage of arteries, which leads to a decrease in the quality of life of patients, an increased risk of limb amputations and death, while the number of patients is measured in millions. In case of suspicion of PAB, the patient undergoes a clinical examination and objective ABI index measurement (ankle-brachial index), as well laboratory tests. In case of confirmed clinical suspicion, imaging tests such as computed tomography angiography (CTA), digital subtraction angiography (DSA) and magnetic resonance angiography (MRA) are used to determine the localization and severity of the disease. After PAB is diagnosed, the decision on further treatment is made at a doctor's council, which usually includes a vascular surgeon, an interventional radiologist and a neurologist, and if necessary, doctors specialized in other fields of medicine. Objective: To determine the frequency of femoral and popliteal artery restenosis over a period of one year in patients treated at the Clinical Hospital Center Rijeka (CHC Rijeka) after treatment with drug-coated balloons (DCB). Another goal of this paper is to compare the obtained results with the results published in the IN.PACT SFA multicenter randomized study. In this way, we will evaluate the success of the procedure performed at CHC Rijeka in relation to the results of other European and international centers. Materials: By searching the databases of the Rijeka Clinical Hospital Center (ISSA and IBIS – integrated hospital information system), data were collected retrospectively on patients who underwent percutaneous transluminal angioplasty (PTA) of the superficial femoral and popliteal arteries using the DCB method from January 1st, 2020 to December 31st of 2020. Results: 79 patients were included in the analysis. The arithmetic mean of the patient's age is 68.32 years (min 39, max 87, st.dev.8.8). The distribution of patients by gender is 20 female patients and 59 male patients. The occurrence of restenosis after treatment was 20.25% (16 people), while 79.75% (63 people) did not experience restenosis in the one-year follow-up period. Conclusion: Results of the research performed at CHC Rijeka show a minimal deviation from the data published in the IN.PACT SFA study in the form of a more frequent occurrence of restenosis in patients treated in our institution compared to the patients included in IN.PACT SFA study (a deviation of 2.45%). The fact that our study was conducted on a smaller sample and that other underlying diseases of the patients as well as the length and degree of stenosis or occlusion were not considered, could be the reason for the earlier mentioned minimal deviations between the two studies. In conclusion, we can say that the observed deviations between the two studies are minimal, but a further, more detailed analysis that would include a larger number of patients and the standardization of inclusion and exclusion criteria is necessary in order to make a more precise conclusion about the success of the method.