Pulmonary vein isolation by cryoablation remains one of the most frequent method in treating paroxysmal atrial fibrillation. The procedure includes adequately occluding pulmonary vein with the ballon cryocatheter and the isolation of the given pulmonary vein. The aim for this study was to calculate the mean value of nadir temperatures from all the pulmonary veins individually and to compare them between each other. In addition to that, comparison has been made between the successful first and multiple-applied cryoablations between the right and the left pulmonary veins. The study was conducted on 40 patients in Clinical hospital centre in Zagreb, to whom the cryoablation has been indicated due to the diagnosed atrial fibrillation. Inclusion criteria are all patients who have been indicated with pulmonary vein isolation due to the diagnosed atrial fibrillation, regardless of age or gender. The processed data have been gathered throughout the entire 2022 year. The results of measurements have been compared with the t-test and chi-squared test. Treshold of the statistical relevance has been set as p < 0,05. Given results imply that the lowest-achieving values of nadir temperatures belong to the upper left pulmonary vein and that there is a statistically relevant difference between it and other pulmonary veins. The largest difference in nadir temperatures is between the upper left and the lower right pulmonary vein (p = 0,00013), due to the lower right pulmonary vein reaching the highest-achieving values of nadir temperatures. The lowest difference was noted between the upper and lower left pulmonary veins (p = 0,031092). In comparison of the lower left pulmonary vein with the other pulmonary veins, it has been noted a lower difference than the ones in upper left pulmonary vein. Despite the lower difference, p-values remain below the 0,05 treshold. The only statistically irrelevant difference was between the nadir temperatures of the upper and lower right pulmonary veins, with their p-value being 0,574184. Other than nadir temperatures, the number of cryoablations is noticeably higher in the right pulmonary veins with mean value being 1,7625. That mean is lower in left pulmonary veins (1,25). The number of isolations achieved with the first cryoablation is much higher in the left (N = 62) than in the right pulmonary veins (N = 35). Comparison of the two shows a p-value being equal to 0,00001249, which shows a large statistically relevant difference. Finally, left pulmonary veins show better results in achieving lower nadir temperatures, as well as in the total number of cryoablatoins and the isolations achieved on the first try.