prikaz prve stranice dokumenta Protective role of strawberry tree ( Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro
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Protective role of strawberry tree ( Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro
Journal of Apicultural Research, x (2022); 1-10. https://doi.org/10.1080/00218839.2022.2047421
Jurič, Andreja; Brčić Karačonji, Irena; Žunec, Suzana; Katić, Anja; Gašić, Uroš; Milojković Opsenica, Dušanka; Kopjar, Nevenka

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Jurič, A., Brčić Karačonji, I., Žunec, S., Katić, A., Gašić, U., Milojković Opsenica, D. i Kopjar, N. (2022). Protective role of strawberry tree ( Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro. Journal of Apicultural Research, x., 1-10. doi: 10.1080/00218839.2022.2047421

Jurič, Andreja, et al. "Protective role of strawberry tree ( Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro." Journal of Apicultural Research, vol. x, 2022, str. 1-10. https://doi.org/10.1080/00218839.2022.2047421

Jurič, Andreja, Irena Brčić Karačonji, Suzana Žunec, Anja Katić, Uroš Gašić, Dušanka Milojković Opsenica i Nevenka Kopjar. "Protective role of strawberry tree ( Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro." Journal of Apicultural Research x (2022): 1-10. https://doi.org/10.1080/00218839.2022.2047421

Jurič, A., et al. (2022) 'Protective role of strawberry tree ( Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro', Journal of Apicultural Research, x, str. 1-10. doi: 10.1080/00218839.2022.2047421

Jurič A, Brčić Karačonji I, Žunec S, Katić A, Gašić U, Milojković Opsenica D, i sur.. Protective role of strawberry tree ( Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro. Journal of Apicultural Research [Internet]. 22.03.2022. [pristupljeno 19.04.2024.];x:1-10. doi: 10.1080/00218839.2022.2047421

A. Jurič, et al., "Protective role of strawberry tree ( Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro", Journal of Apicultural Research, vol. x, str. 1-10, Ožujak 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:234858. [Citirano: 19.04.2024.]

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Naslov (engleski)Protective role of strawberry tree ( Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro
AutorAndreja Jurič
AutorIrena Brčić Karačonji
AutorSuzana Žunec
AutorAnja Katić
AutorUroš Gašić
AutorDušanka Milojković Opsenica
AutorNevenka Kopjar
Autorova ustanovaSveučilište u Rijeci
Fakultet zdravstvenih studija
(Katedra za temeljne medicinske znanosti)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Strawberry tree (Arbutus unedo L.) honey (STH) is widely used as part of traditional medicine in the Mediterranean area, especially in the treatment of wounds, burns and infections. In this study, we investigated the cyto-/genoprotective properties of STH at cell level following short-term exposure to UVB radiation at 2 kJ/m2. Isolated human peripheral blood lymphocytes (PBL) were selected as model cells. Phenolics in STH were determined using an ultra-high-performance liquid chromatograph (UHPLC) coupled to a linear ion trap-Orbitrap hybrid mass spectrometer (LTQ Orbitrap MS), while homogentisic acid (HGA) was quantified using a gas chromatograph-mass spectrometer (GC-MS). Primary DNA damage in PBLs treated with STH before and after irradiation was assessed by alkaline comet assay, while their viability was determined using the apoptosis/necrosis assay. The levels of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) were determined in plasma samples. STH applied as pre-treatment at a concentration equivalent to its average daily portion efficiently counteracted the cytotoxic and genotoxic effects and diminished UVB-induced oxidative stress. Post-radiation treatment with STH was not as beneficial. Protective effects could be associated to the complex phytochemical profile of STH and the high content of HGA (306.8 mg/kg). It was confirmed that an intake of a complex mixture of bioactive constituents as STH prior to potential cyto/genotoxic insults stimulated a broad-spectrum of protective mechanisms, including intracellular antioxidative defence and DNA repair systems that helped pre-treated cells to counteract harmful exposures more efficiently.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Apicultural Research
Brojčani podacivol. x, str. 1-10
p-ISSN0021-8839
e-ISSN2078-6913
DOIhttps://doi.org/10.1080/00218839.2022.2047421
URN:NBNurn:nbn:hr:184:234858
Datum objave publikacije2022-03-22
URL dokumentahttps://www.tandfonline.com/doi/full/10.1080/00218839.2022.2047421
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
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Datum i vrijeme pohrane2024-01-15 13:51:22